(3b,16a)-3-(Acetyloxy)-16-hydroxy-24-methylenelanost-8-en-21-oic acid
Pachymic acid
CAS: 29070-92-6
Molecular Formula: C33H52O5
(3b,16a)-3-(Acetyloxy)-16-hydroxy-24-methylenelanost-8-en-21-oic acid - Names and Identifiers
| Name | Pachymic acid |
| Synonyms | PACHYMIC ACID Pachymic acid 3-ACETYLTUMULOSIC ACID 24-methylene-,(3β,16α)- 3-O-Acetyltumulosic acid Pachymic acid (3-O-Acetyltumulosic acid) Lanost-8-en-21-oic acid, 3-(acetyloxy)-16-hydroxy- 3β-Acetyloxy-16α-hydroxy-24-methylenelanost-8-en-21-oic acid 3-(acetyloxy)-16-hydroxy-24-methylidenelanost-8-en-21-oic acid (3b,16a)-3-(Acetyloxy)-16-hydroxy-24-methylenelanost-8-en-21-oic acid (3beta,16alpha,20R)-3-(acetyloxy)-16-hydroxy-24-methylidenelanost-8-en-21-oic acid |
| CAS | 29070-92-6 |
| InChI | InChI=1/C33H52O5/c1-19(2)20(3)10-11-22(29(36)37)28-25(35)18-33(9)24-12-13-26-30(5,6)27(38-21(4)34)15-16-31(26,7)23(24)14-17-32(28,33)8/h19,22,25-28,35H,3,10-18H2,1-2,4-9H3,(H,36,37)/t22-,25-,26+,27+,28+,31-,32-,33+/m1/s1 |
(3b,16a)-3-(Acetyloxy)-16-hydroxy-24-methylenelanost-8-en-21-oic acid - Physico-chemical Properties
| Molecular Formula | C33H52O5 |
| Molar Mass | 528.76 |
| Density | 1.10±0.1 g/cm3(Predicted) |
| Melting Point | 300 °C(Solv: methanol (67-56-1); acetone (67-64-1)) |
| Boling Point | 612.2±55.0 °C(Predicted) |
| Specific Rotation(α) | (Py)+17.7 |
| Flash Point | 184.7°C |
| Solubility | Soluble in pyridine |
| Vapor Presure | 1.51E-17mmHg at 25°C |
| Appearance | White needle crystal powder |
| Color | White to Off-White |
| pKa | 4.65±0.10(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
| Refractive Index | 1.539 |
| MDL | MFCD00238657 |
| Physical and Chemical Properties | Easily soluble in pyridine derived from Polyporaceae of the family Polyporaceae, wolfiporia Cocos dried sclerotia of poria cocos |
| In vitro study | Pachymic acid (PA) is able to inhibit gallbladder cancer tumorigenesis involving affection of Akt and ERK signaling pathways. Pachymic acid (PA) treatment significantly inhibits Rho A, Akt and ERK pathway in gallbladder carcinoma cells. Pachymic acid (PA) treatment can dose-dependently downregulate PCNA, ICAM-1, RhoA, p-Akt and pERK. Cell growth is inhibited by 10 µg/mL Pachymic acid (PA) 12 h after treatment, and a concentration of 30 µg/mL further reduced cell growth. The growth of cells is suppressed in a time- and dose-dependent manner. After 48 h treatment, about 25%, 40% and 70% of the cell growth are inhibited by Pachymic acid (PA) at concentration of 10 µg/mL, 20 µg/mL and 30 µg/mL, respectively. Pachymic acid (PA) also inhibits the growth of gallbladder carcinoma cells in a time-dependent and dose-dependent manner. |
| In vivo study | To evaluate the anti-tumor activity of Pachymic acid (PA) in vivo, human lung cancer NCI-H23 tumor xenograft models are used. Pachymic acid (PA) significantly suppresses tumor growth at doses of 30 and 60 mg/kg for 21 days compared with the control group. |
(3b,16a)-3-(Acetyloxy)-16-hydroxy-24-methylenelanost-8-en-21-oic acid - Reference
| Reference Show more | 1. Wu Wen Wu Rui Feng Kang Jiang Li. Study on the fingerprint and content determination of Shenling Jianwu powder [J]. China pharmacist 2019 22(05):852-856. 2. Du Fangping, Chen Weidong, Zhu Yuejian, et al. Study on the content of poria cocos polysaccharide and pachymic acid in the artificial wild cultivation poria cocos in Dabie Mountain area [J]. Anhui medical journal, 2015, 19(009):1681-1683. 3. Cai Danfeng, Chen Danhong. Accumulation characteristics of main nutrient components in poria cocos cultivated in Pinus massoniana [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 033(001):373-375. 4. Lan Xin-Cai, Wu Ye-Feng, Wang Mai-Li, et al. Optimization of extraction process of active components from poria cocos [J]. Chinese Journal of Veterinary Medicine, 2015, 49(1):14-18. 5. Yu Bin, Zhu Wenxue, Bai Xiting, etc. Optimization of ultrasonic enhanced drying process of poria extract [J]. Food Research and Development, 2018, 25 (1):74-79. 6. Dong Jianshe, Zhao Junfeng, Zhang Linchao, et al. Effect of pachymic acid on biological characteristics of renal cell carcinoma cells through Wnt signaling pathway [J]. Chinese Journal of Gerontology, 2019, 39(09):198-201. 7. Zhao qiulong, bianxiaokun, Qian Dawei, Shulan, Guo Sheng, Wang Tuanfeng, Duan Jinyu. Metabolites of Guizhi Fuling capsule in plasma, bile, urine and feces of primary dysmenorrhea model rats [J]. Journal of Pharmaceutical Analysis, 2021,41(01):51-63. 8. Liu, Zhenhong, et al.. "Brain and behavior 10.5 (2020): e01602 https:// doi.org/10.1002/brb3.1602 9. [IF = 5.34] Shangmin Yu et al." nNovel insights into antidepresant mechanism of Kai Xin San formula: inhibiting NLRP3 inflammasome activation by promoting autophagy."Phytomedicine. 2021 Oct;:153792 10. [IF=3.512] Binbin Wang et al."Comprehensive Quality Assessment of Kaixin Powder by HPLC-DAD Quantification and HPLC-QTOF-MS/MS Confirmation."Acs Omega. 2021;6(17):11319-11326 11. [IF=2.091] Zhenhong Liu et al."GAPT regulates cholinergic dysfunction and oxidative stress in the brains of learning and memory impairment mice induced by scopolamine."Brain Behav. 2020 May;10(5):e01602 |
(3b,16a)-3-(Acetyloxy)-16-hydroxy-24-methylenelanost-8-en-21-oic acid - Reference Information
| basic information | appearance and properties: white powder flash point: 184.7°C density: 1.1g/cm3 boiling point: 612.2°C at 760 mmHg refractive index: 1.539 vapor pressure: 1.51 E-17mmHg at 25°C |
| use | poria cocos is a unique component of traditional Chinese medicine poria cocos and one of the main active components of poria cocos. it has a variety of pharmacological activities related to drug effect. At present, pachytic acid has attracted extensive attention and has been studied more and more. Pachytic acid is widely used in anti-tumor, anti-inflammatory, antioxidant, hypoglycemic, sedative and hypnotic aspects. for content determination/identification/pharmacological experiments and other pharmacological effects: it has cytotoxic effect on liver, can competitively inhibit the biological activity of phospholipase A2(phospholipase A2,PLA2) and reduce PLA2-mediated cell damage. |
| References | http://www.chemsrc.com/cas/54239-37-1_671704.html |
| biological activity | Pachymic acid is a triterpenoid from P. cocos. Pachymic acid inhibits Akt and ERK signaling pathways. |
Last Update：2024-04-09 20:52:54
Supplier List
Featured ProductsMultiple SpecificationsSpot supply
Product Name: Pachymic acid Visit Supplier Webpage Request for quotationCAS: 29070-92-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Pachymic Acid Visit Supplier Webpage Request for quotationCAS: 29070-92-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Featured ProductsMultiple SpecificationsSpot supply
Product Name: Pachymic acid Visit Supplier Webpage Request for quotationCAS: 29070-92-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Pachymic Acid Visit Supplier Webpage Request for quotationCAS: 29070-92-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
View History